Immunometabolic depression: from conceptualization towards implementation

Abstract The burden on society by depression is undisputable, partly due to a chronic course pattern and depression’s large heterogeneity that contributes non-response standard treatments. Using data from the Netherlands Study of Depression Anxiety (NESDA, www.nesda.nl ), Penninx will illustrate both points. When examining depression, especially when also considering transitions into other affective disorders over time, chronicity clearly more rule than exception (Verduijn et al. BMC Med 2017). Considering could lead precision psychiatry approaches help reduce chronicity. Immuno-metabolic dysregulations seem vary as function heterogeneity: map consistently “atypical” neurovegetative symptoms reflecting altered energy intake/expenditure balance (hyperphagia, weight gain, hypersomnia, fatigue leaden paralysis). Findings are confirmed utilizing genome-wide gene expression well DNA information (Milaneschi Biol Psychiatry 2020). Preliminary treatment studies suggest presence immuno-metabolic in moderates antidepressant effects or novel (immunomodulatory) interventions. An dimension dissect potentially match depressed subgroups treatments with higher likelihood clinical success. Disclosure Interest None Declared